From Yahoo! health:
Change your toothbrush at least once a month, or right after a cold, flu or other illness. Germs that can live on a damp toothbrush for days; when you're sick, a damp toothbrush may reinfect you. Use two toothbrushes alternately to give each one a chance to completely dry out. "Brushing your teeth is a traumatic injury," says Dr. Charles J. Palenik, a microbiologist at the Indiana University School of Dentistry. "You are going into areas of your mouth where you can have bleeding, and you could be reintroducing organisms back into your system."
Change your toothbrush at least once a month, or right after a cold, flu or other illness. Germs that can live on a damp toothbrush for days; when you're sick, a damp toothbrush may reinfect you. Use two toothbrushes alternately to give each one a chance to completely dry out. "Brushing your teeth is a traumatic injury," says Dr. Charles J. Palenik, a microbiologist at the Indiana University School of Dentistry. "You are going into areas of your mouth where you can have bleeding, and you could be reintroducing organisms back into your system."